【摘 要】
:
Traditional Chinese medicine (TCM) is a system of therapies that has developedthrough empiricism for over 2100 years and has remained a popular alternative medicinein some Far East Asian populations..
【机 构】
:
江西中医药大学 中医基础理论分化发展研究中心 江西中医药大学现代中药制剂教育部重点实验室
【出 处】
:
中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议
论文部分内容阅读
Traditional Chinese medicine (TCM) is a system of therapies that has developedthrough empiricism for over 2100 years and has remained a popular alternative medicinein some Far East Asian populations..Studies in TCM suggest that there is an intimate connectionbetween pharmacology of TCM and regulating ATP homeostasis.In this review, current advances of TCM in manipulating ATP production and utilization, including regulatingcatabolism of large molecules, proton gradient,the electron transfer chain activity, ATPase activity, and altering structure mitochondria, and energy charge, are summarized.Finally, some issues related to ATP manipulation are addressed.
其他文献
The bitter tastant chloroquine activates bitter taste receptors (TAS2Rs) and signaling through G protein subtype Gβγ to increase intracellular Ca2+ in airway muscle cells,and this Ca2+ increase result
膀胱癌是我国泌尿生殖系统最常见的肿瘤,其发病率和死亡率均居泌尿肿瘤首位.膀胱癌的演进是多阶段多基因参与的结果,其中DNA损伤应答过程的异常可通过影响细胞周期、凋亡和DNA修复等重要生命活动导致肿瘤基因组的高度不稳定,与肿瘤的发生、发展密切相关.
慢性粒细胞白血病(CML)是正常造血干细胞获得性形成BCR-ABL融合基因而诱发的克隆性血液肿瘤.抑制BCR-ABL酪氨酸激酶的小分子化合物,如Imatinib mesylate能使慢性期患者得到有效缓解,但单一药物尚不能治愈该疾病;这表明深入研究CML致病分子机制、寻找新的治疗靶标仍是CML研究的重点.
Taurine,a conditional essential amino acid,plays a critical role in cardiovascular functions.Here we examined the effects of taurine on mitochondria and Endoplasmic Reticulum in rat cardiomyocytes dur
Huntingtons disease (HD) is a progressive neurodegenerative disorder caused by thepolyglutamine (polyQ) expansion in huntingtin (Htt) protein, a ubiquitously expressed proteinof yet unknown function.G
To analyze the backbone dynamics of AK1, we performed 15N relaxation measurementsusing NMR spectroscopy.Totally,115 assigned residues were used except the residueswith overlapping signals that were no
Raft kinase inhibitor protein (RKIP) directly interacts with Rafl kinase, thereby regulatingthe Rafl/MEK/ERK pathway which is vital for cell growth and differentiation.However, little is known about t
Really interesting new gene (RING) finger protein is a large protein family in the humangenome.And have very important functions in physiological activities and cancer development.The biological funet
Experimental study of the role of disorder in protein function is challenging.It has beenproposed that proteins utilize disordered regions in the adaptive recognition of their variousbinding partners.
Dihydrofolate reductase (DHFR) is a household enzyme involved in many biosyntheticpathways including purine synthesis.The enzymatic reaction involves converting dihydrofolate(DHF) to tetrahydrofolate