Novel mechanisms of bitter tastant inducing mouse airway smooth muscle cell contraction and relaxati

来源 :中国细胞生物学学会2013年全国学术大会 | 被引量 : 0次 | 上传用户：sweetyjiaxin

【摘要】

：

【作者】

：

Ting Zhang Wen-Er Li Yun-Fei Ma Meng-Fei Yu Wen-Bo Sai Jinhua Shen Yun-Min Zheng Yong-Xiao Wang Guangju Ji Qing-Hua Liu

【机构】

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Institute for Medical Biology,College of Life Sciences,South-Central University for Nationalities,Wu

【出处】

：

中国细胞生物学学会2013年全国学术大会

【发表日期】

：

2013年12期

【关键词】

：

tas2r bitter tastant airway muscle non-selection cation channels airway hyperres

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The bitter tastant chloroquine activates bitter taste receptors (TAS2Rs) and signaling through G protein subtype Gβγ to increase intracellular Ca2+ in airway muscle cells,and this Ca2+ increase results in relaxation of either resting or precontracted airway muscle.Such relaxation is partially mediated by high-conductance K+ channels (Nature Medicine,2010,16,P1299-1304).

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Novel mechanisms of bitter tastant inducing mouse airway smooth muscle cell contraction and relaxati

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