The cytochrome P450 epoxygenasesoluble epoxide hydrolase axis in endothelial signalling and vascular

来源 :2013 Shanghai Symposium on Polyunsaturated Fatty Acids and M | 被引量 : 0次 | 上传用户：viclee0716

【摘要】

：

Fatty acid epoxides are important lipid signaling molecules involved in the regulation of vascular tone and homeostasis.Tissue and plasma levels of these mediat

【作者】

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Ingrid Fleming

【机构】

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InstituteforVascularSignalling,CentreforMolecularMedicine,GoetheUniversity,Frankfurt,Germany

【出处】

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2013 Shanghai Symposium on Polyunsaturated Fatty Acids and M

【发表日期】

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2013年6期

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Fatty acid epoxides are important lipid signaling molecules involved in the regulation of vascular tone and homeostasis.Tissue and plasma levels of these mediators are determined by the activity of cytochrome P450 (CYP) epoxygenases and the soluble epoxide hydrolase (sEH) and targeting the latter is an effective way of manipulating epoxide levels in vivo.We investigated the role of the sEH in regulating the mobilization and proliferation of progenitor cells with vaseulogenic/reparative potential.

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The cytochrome P450 epoxygenasesoluble epoxide hydrolase axis in endothelial signalling and vascular

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