【摘 要】
：
A number of studies during the past decades have suggested a critical role of glutamatergic N-methyl-D-aspartate (NMDA) receptors in learning and memory pro
【机 构】
：
Department of Physiology and Pathophysiology, Medical School of Xi'an Jiaotong University, Xi'an 7
【出 处】
：
中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
A number of studies during the past decades have suggested a critical role of glutamatergic N-methyl-D-aspartate (NMDA) receptors in learning and memory processes.Induction of hippocampal long-term potentiation (LTP) has been shown to require the activation of NMDA receptors.On the other hand,antagonists of the NMDA receptors,such as AP5,MK-801,and phencyclidine (PCP) have been proved to block hippocampal LTP in vitro and to impair hippocampal-dependent behavior,for example,place and spatial leaming.These findings have led to the suggestions that NMDA receptors play a critical role in cognitive functions involving corticohippocampal circuits and that mechanisms underlying LTP and the behavioral manifestations of spatial learning are related.But most research got the results through using antagonists of NMDA receptor or destroying the hippocampal structures.
其他文献
Our previous studies have shown that Lmxlb expression at the mid/hindbrain boundary (MHB) is essential for the development of the tectum and cerebellum by c
α-Synuclein基因是一种重要的帕金森病(Parkinsons disease,PD)相关蛋白,其异常表达和聚集会造成DA能神经元的毒性.酪氨酸羟化酶(tyrosine hydroxylase,TH)是DA合成过程
目前,神经干细胞的研究多集中于脑源性神经干细胞的研究,对脊髓源性神经干细胞的研究为数不多。实验证明,在胚胎以及成体的脊髓中有神经干细胞的存在,成年哺乳动物脊髓室
青海省黄南州藏族人群头虱感染状况调查李承宁，秦海萍（青海省黄南州卫生防疫站８１１３００）王华妮（青海省黄南州人民医院）头虱病是一种古老的体外寄生虫病，多年来在黄南藏族世居的农牧区广泛流
Parkinsons disease(PD) is a common chronic neurodegenerative disorder,which is characterized by progressive degeneration of dopaminergic neurons in the subs
The differentiation and migration of superficial dorsal horn neurons and subsequent ingrowth of primary afferents are crucial in the formation of somatosens
由天津市农机试验鉴定推广站开发研制的ORJ-80SA型双跨悬臂式卷帘机,适用于长度50～80m,跨度6～8m日光温室草帘、保温被的卷铺。可在6min内一次性完成温室草帘、保温被的自动卷
随着服务提供商向其基于MTU和MDU的客户推出IPTV和“三合一”业务,向多个用户同时提供持续并可随时间调整带宽的能力开始显得至关重要。日前BroadLight公司推出了面向高性能
１６０５８名汽车学员健康状况复查分析广东省汕头市职业病防治所（红领巾路，５１５０４１）陈玩琴随着经济建设的发展，给交通运输业带来兴旺，也带来新的问题。车多路窄，导致交通事故繁多已成当今社会公害之
The cadherin/catenin complex is an important cell adhesion complex that been shown to have many important physiological functions during neural development