Long noncoding RNAs (lncRNAs) are emerging as new players in gene regulation and associated with the development and progression of a variety of human cancers.However,to date,the biological functions
Cancer stem-like cells (CSLCs) are responsible for the unrestrained growth and chemo-resistance of malignant tumors.Histone demethylation is crucial for self-renewal/differentiation of stem cells,but
Gastric cancer(GC) is one of the most common cancers with a poor prognosis worldwide.The calcium sensing receptor (CaSR),a GPCR C family member,is functionally expressed in the entire gastrointestinal
Background hTERT is an ideal anticancer target because it is universally expressed in cancer cells and plays a crucial role in carcinogenesis.In our previous study,we demonstrated that over-expression
Background Gastric cancer (GC) is one of the most common tumors and the molecular mechanism underlying its metastasis is still largely unclear.Methods the miR-25 expression in primary tumors tissues a
Objective To investigate effects of octreotide on fatty infiltration of the pancreas in high-fat diet induced obesity rats.Methods SD rats were divided into control group (n=14) and high-fat diet grou
Objective To investigate the effects of FOXM1 on Mcl-1 expression and the relevant mechanism,and on the sensitivity to oxaliplatin in gastric cancer cells.Methods and Materials (1) Immunohistochemical
目的:肠道细菌移位(Bacterial Translocation,BT)在肝硬化(Liver Cirrhosis,LC)及其并发症的发生和发展中发挥着重要作用,但肠黏膜天然免疫对LC肠道细菌移位、LC及其并发症发生、发展的影响仍不清楚.TLR4-NFκBP65-TNF-a及NALP3-ASC-IL-1β是最主要的肠粘膜天然免疫通路.本研究旨在探索LC肠道细菌移位大鼠肠粘膜天然免疫变化,明确该变化
目的 研究创伤后应激障碍(PTSD)状态下，超极化激活环核苷酸门控阳离子通道2(HCN2) 与谷氨酸转运体-1(GLT-1)在脊髓水平协同调控内脏高敏感性—中枢敏化的作用及机制。方法 选用成年雌性SD大鼠，随机分为3组：正常对照组(14只)、PTSD组(15只)、PTSD + CTX组(15只)，每组中各有7只用于HCN2 免疫荧光检测，其余用于内脏敏感性测定。
背景:研究表明肝硬化和门静脉高压时肝脏存在大量新生血管,肝脏环氧化物合酶-2(COX-2)的表达与肝硬化程度密切相关.选择性COX-2 抑制剂塞来昔布是一种有效的血管新生抑制剂,其在肝硬化和门静脉高压治疗中的作用尚不明确,需进一步的研究.方法:使用硫代乙酰胺(TAA)腹腔注射(200mg/kg,每三天一次共16周)诱导SD 大鼠肝硬化模型.36 只SD 大鼠随机分为三组:塞来昔布组接受TAA+塞来