Achaete scute-like 2 (Ascl2),a basic helix-loop-helix (bHLH) transcription factor,is a downstream target of Wnt signaling that controls the fate of intestinal cryptic stem cells and colon cancer proge
This study examined whether O-glycans are involved in EPEC and EHEC O157:H7 adherence to intestinal epithelial cells.A comparison of the adherence of EPEC and EHEC O157:H7 to HT-29-Gal and HT-29 cells
Long noncoding RNAs (lncRNAs) are emerging as new players in gene regulation and associated with the development and progression of a variety of human cancers.However,to date,the biological functions
Cancer stem-like cells (CSLCs) are responsible for the unrestrained growth and chemo-resistance of malignant tumors.Histone demethylation is crucial for self-renewal/differentiation of stem cells,but
Gastric cancer(GC) is one of the most common cancers with a poor prognosis worldwide.The calcium sensing receptor (CaSR),a GPCR C family member,is functionally expressed in the entire gastrointestinal
Background hTERT is an ideal anticancer target because it is universally expressed in cancer cells and plays a crucial role in carcinogenesis.In our previous study,we demonstrated that over-expression
Background Gastric cancer (GC) is one of the most common tumors and the molecular mechanism underlying its metastasis is still largely unclear.Methods the miR-25 expression in primary tumors tissues a
Objective To investigate effects of octreotide on fatty infiltration of the pancreas in high-fat diet induced obesity rats.Methods SD rats were divided into control group (n=14) and high-fat diet grou
Objective To investigate the effects of FOXM1 on Mcl-1 expression and the relevant mechanism,and on the sensitivity to oxaliplatin in gastric cancer cells.Methods and Materials (1) Immunohistochemical
目的:肠道细菌移位(Bacterial Translocation,BT)在肝硬化(Liver Cirrhosis,LC)及其并发症的发生和发展中发挥着重要作用,但肠黏膜天然免疫对LC肠道细菌移位、LC及其并发症发生、发展的影响仍不清楚.TLR4-NFκBP65-TNF-a及NALP3-ASC-IL-1β是最主要的肠粘膜天然免疫通路.本研究旨在探索LC肠道细菌移位大鼠肠粘膜天然免疫变化,明确该变化