肠黏膜天然免疫在肝硬化肠道细菌移位中的作用

来源 :第17届西南地区消化病学术会议暨2014贵州省消化病及消化内镜学术年会 | 被引量 : 0次 | 上传用户:yaonulio
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目的:肠道细菌移位(Bacterial Translocation,BT)在肝硬化(Liver Cirrhosis,LC)及其并发症的发生和发展中发挥着重要作用,但肠黏膜天然免疫对LC肠道细菌移位、LC及其并发症发生、发展的影响仍不清楚.TLR4-NFκBP65-TNF-a及NALP3-ASC-IL-1β是最主要的肠粘膜天然免疫通路.本研究旨在探索LC肠道细菌移位大鼠肠粘膜天然免疫变化,明确该变化对全身免疫炎症反应及多器官组织病理损伤的影响.
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