【摘 要】
：
The p53 gene has been widely investigated and considered to be an effective tumor suppressor in cancer gene therapy [1].To realize the clinical application
【机 构】
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Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education,School of Life Scie
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
The p53 gene has been widely investigated and considered to be an effective tumor suppressor in cancer gene therapy [1].To realize the clinical application ofp53-based gene therapy,developing safe and efficient gene carriers is necessary.Non-viral gene carriers including 25 kDa branched polyethylenimine (PEI25K) have been demonstrated to be more promising than viral carriers.However,the inherent shortcomings of PEI25K,such as cytotoxicity,adsorption of serum proteins and acceleration of reticuloendothelial system removal,would significantly limit its application scope.
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