【摘 要】
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Understanding of principles governing selective and sensitive cancer targeting is critical for development of chemicals in cancer diagnostics and treatments.We determined how a fluorescent small organ
【机 构】
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Institute of Atomic and Molecular Sciences, Academia Sinica Taiwan
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Understanding of principles governing selective and sensitive cancer targeting is critical for development of chemicals in cancer diagnostics and treatments.We determined how a fluorescent small organic molecule, 3,6-bis(1-methyl-4-vinylpyridinium) carbazole diiodide (BMVC), selectively labels cancer cells but not normal cells.We show that BMVC becomes trapped in the lysosomes of normal cells, whereas in cancer cells, BMVC escapes the lysosomes and emits strong fluorescence upon binding to the nuclear and mitochondrial DNA.In addition, we found that drug-resistant cancer cells with less lysosomal membrane permeability than drug-sensitive cells preferentially retain BMVC in their lysosomes.
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