【摘 要】
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We conducted a meta-analysis to assess whether ETS and ST can guide anti-EGFR MoAb treatment in metastatic colorectal cancer (mCRC) patients.The correlation of ST and ETS with benefit acquired from ad
【机 构】
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Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University,Clinical Ca
【出 处】
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2015苏浙皖赣肿瘤内科治疗进展高峰论坛暨江苏省第七次肿瘤化疗与生物治疗学术会议
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We conducted a meta-analysis to assess whether ETS and ST can guide anti-EGFR MoAb treatment in metastatic colorectal cancer (mCRC) patients.The correlation of ST and ETS with benefit acquired from additional anti-EGFR treatment and the correlation of ST with quality of life.Pooled Hazard ratio (HR) and rate difference (RD) were all estimated by using random-effects model.Pooled data from 28 studies with 5060 patients revealed that the occurrence of ST and a cut-off value of ETS≥20％ (v＜20％) during anti-EGFR MoAb treatment were both associated with longer OS, PFS and ORR.Similarity, relevant evidences also suggested that only wild-KRAS patients with ETS could benefit from additional anti-EGFR treatment, and the more early shrinkage the tumor was, the more benefit degree was observed.These data confirmed the prognostic role of ETS and ST in mCRC patients and these two on-treatment markers are predictive of benefit acquired from anti-EGFR treatment in wild-KRAS tumors.
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