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Human noroviruses (huNoVs) are the most important viral pathogens causing epidemic acute gastroenteritis (AGE),in which the GⅡ.4 viruses have been predominant worldwide for the past decades.During the past huNoV season,a new GⅡ.17 variant was noted to emerge as a predominant virus in China surpassing the GⅡ.4 virus in causing significantly increased AGE outbreaks.