【摘 要】
：
Objective: Since the first report of osteonecrosis of the jaw associated with bisphosphonates administration in 2003,there have been many efforts to understand the nature of disease.This study was to
【机 构】
：
Dept.of Oral and maxillofacial surgery,Ewha Womans University Medical center;Dept.of Oral and Maxill
【出 处】
：
11th Asian Congress on Oeal and Maxillofacial Surgery(第十一届亚洲
论文部分内容阅读
Objective: Since the first report of osteonecrosis of the jaw associated with bisphosphonates administration in 2003,there have been many efforts to understand the nature of disease.This study was to investigate the potential biomarker of bisphosphonate related osteonecrosis of jaw.Methods: A total of 48 ovariectomized 8-week SD rats were randomly divided into two groups.Case group was administrated zoledronic acid (0.2mg/kg/week) (n =36).Control received normal saline (n =12).After 6 weeks injection for each group, tooth extractions (lower M1-3) as a dental intervention inducing osteonecrosis of jaw were performed.Further injections followed after 8 weeks.Urine and blood samples were gathered for further analysis at the day of starting injection (T0), tooth extractions (T1), euthanasia (T2).Clinical and histological determination of BRONJ occurrence were assessed for case group.The animals were classified according to results.For biomarker evaluation,tartrate resistant acid phosphatase 5b (TRACP 5b), CTx, alpha and beta CTx, receptor activator of nuclear factor kB ligand (RANKL), osteoprotegerin (OPG), osteopontin and bone sialoprotein concentrations were determined using rat ELISA kits in accordance with the manufacturers instructions.For statistical analysis, Kruskal-Wallis test, MannWhitney test and Linear mixed model analysis were performed.
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