Expression of hypoxia-inducible factor 1α is associated with lymph node metastasis in oral squamous

来源 :11th Asian Congress on Oeal and Maxillofacial Surgery(第十一届亚洲 | 被引量 : 0次 | 上传用户：X22521

【摘要】

：

【作者】

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Jian-nan Li Zh-ien Feng Chuan-bin Guo

【机构】

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Department of Oral and Maxillofacial Surgery,School of Stomatology,Peking University Beijing 100081,

【出处】

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11th Asian Congress on Oeal and Maxillofacial Surgery(第十一届亚洲

【发表日期】

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2014年3期

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Objective: Hypoxia plays a fundamental role in tumor progression.Hypoxia inducible factor 1 is a key regulator of the cellular response to hypoxia.Expression of the HIF-1 α subunit was reported to be associated with a poor prognosis in a variety of malignant tumors.The objective of this study was to explore the association between HIF-1α expression and lymph node metastasis in oral squamous cell carcinoma (OSCC).

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