【摘 要】
：
Neurodegenerative diseases are the nerve disorders caused by gradual loss of neurons in patient brains.These diseases are now known to result,directly or indirectly,from aberrant protein folding and a
【机 构】
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Shanghai Institute of Biochemistry and Cell Biology, CAS
【出 处】
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第十五届亚太分子生物学网络组织年会
论文部分内容阅读
Neurodegenerative diseases are the nerve disorders caused by gradual loss of neurons in patient brains.These diseases are now known to result,directly or indirectly,from aberrant protein folding and aggregation.The misfolded proteins or aggregates are apparently targeted for refolding by molecular chaperones or degradation by ubiquitin-proteasome system (UPS).A group of multi-domain co-chaperones,such as CHIP,HSJI.USP19 and BAG proteins,may play roles in orchestrating the client protein levels in cells through combination of chaperone and UPS pathways.We studied the effects of some dual-function co-chaperones on the protein levels of both normal and the disease-related forms of polyglutamine (polyQ)-expanded amyloidogenic proteins,ataxin-3 (Atx3),huntingtin (Htt) or ataxin-7 (Atx7).
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