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glycoforms is compromised by misguided quest for numbers.Given the non-template encoded nature of glycosylation,it is arguable that whether one needs to delineate every single glycoform and glycomic entity.We propose instead to develop and implement workflows that focus on in depth analysis of glycotopes and specific target glycoproteins.How different mass spectrometry techniques currently available can be utilized judiciously and in concert will be demonstrated in this presentation using specific case examples.These include complementary modes of fragmentation that can be acquired in parallel or in product ion dependent manner with increasing speed and sensitivity,the high resolution accurate mass capability at not only MS1 but also MS2/MS3 level,and the requisite informatics solutions.At all stages,we abide by the principle that which is less complicated is often better understood and more appreciated than what is more complicated.Homing in on the few glycotopes and makes such analysis amenable to all non-experts at high throughput confers a better mileage than aiming at unraveling the full glycomic complexity to no avail.