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Aim To evaluate the influence of extended care on living quality of patients after allogeneic hematopoietic stem transplantation.Methods A total of 80 patients after allogeneic hematopoietic stem transplantation were enrolled in this study.They were randomly divided into intervention group and control group according to hospital number ending(odd and even numbers).The intervention group cases were given the extended care after discharging from hospital, but no intervention for the control group,and the quality of life was evaluated by using cancer patients quality of life measure scale developed by European Organization for research and treatment of cancer(EORTC) in the two groups at 1 month and 3 months after discharged.Results At 1 month after discharge,the cognitive function score and emotion function score in intervention group were better than that of control group;at 3 months after discharge,the scores of physical function,role function,cognitive function,social function,general health status and fatigued,insomnia symptoms in intervention group were better than that of control group.Conclusion: Extended care for patients after allogeneic hematopoietic stem transplantation can effectively improve the quality of life of them.