【摘 要】
：
In recent years,developing bioinspired delivery systems has attracted wide attentions in the field of biomedical nanomaterials for cancer therapy.With the rational molecular and supramolecular enginee
【机 构】
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四川大学,国家生物医学材料工程研究中心
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
In recent years,developing bioinspired delivery systems has attracted wide attentions in the field of biomedical nanomaterials for cancer therapy.With the rational molecular and supramolecular engineering,we fabricated peptide dendritic assemblies mimicking viral architectures and infections for overcoming key biological barriers and navigating systemic delivery,which are able to resist protein adsorption,prolong blood circulation time,as well as provide site-specific drug delivery by passive targeting,extracellular targeting,receptor-mediated active targeting and subcellular targeting.More importantly,capsid-like supramolecular dendritic systems could realize deep tumor drug penetration.In vitro and in vivo results confirmed that the multifunctional viral mimics provided much better tumor treatment effects as compared with positive control group,including the aspects of tumor growth inhibition,side effects,and tumor metastasis.On the other hand,molecular probe could be readily incorporated into supramolecular dendritic systems for tumor diagnosis.We built a dual-responsive supramolecular PEGylated dendritic system which was integrated fluorescent probe after disulfide polymerization for efficient platinum-based drug delivery and near-infrared(NIR)tracking.
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