Inactivation of corticotropin releasing hormone-induced insulinotropic role by high-altitude hypoxia

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户:badgod
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  We have shown that hypoxia reduces plasma insulin,which correlates with corticotropin-releasing hormone(CRH)receptor 1(CRHR1)in rats,but the mechanism remains unclear.Here,we report that hypobaric hypoxia of 5,000 m altitude for 8 h enhanced rat plasma CRH,corticosterone,and glucose levels,while plasma insulin and pancreatic ATP/ADP ratio were reduced.
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