Multinucleation and Cellular Dysfunction in Human Hepatic Cell line L-02 Induced by Amorphous Silica

• 作 者: Wen Wang Zhiwei Sun Yang Li Xiaomei Liu Minghua Jin Haiying Du Ying Liu Peili Huang Xianqing Zhou Lan yuan
• 机 构: School of Public Health, Jilin University, Changchun, Jilin, 130021, P.R.China
• 出 处: 首都医科大学公共卫生学院第五届学术年会
• 发表日期: 2013年4期
• 关键词: Silica nanoparticles human hepatic cell L-02 multinucleation cell cycle cellular

　　Silica nanoparticles, as one of the most important nanomaterials, has been widely used in a variety of fields.Thus, their effects on human health and environment have been addressed in several studies.In this paper, the multinucleation effects of amorphous silica nanoparticles (SNPs) were investigated in human hepatic L-02 cells.Results showed that L-02 cells displayed an abnormal high incidence of multinucleation that increased with silica dose.