主要内容 Outlines Phosphorylation and signal transduction Oncogenic PTPN11/SHP2 in temporal and spatial manner Tyrosine phosphatase Shp2 regulates lung epithelial injuries and inflammation Shp2 signalosom
The tradition chemotherapy for patients with advanced breast cancer has sever toxicity and poor curative effect.Metronomic chemotherapy is a kind of ‘low dose’ and ‘long continuous dosing’ chemotherap
Objective:To observe efficacy and security of five chemotherapeutic schemes including platinum on advanced nonsmall-cell lung cancer.Methods:Three hundreds NSCLC patients were randomed into five group
Background: The expression of TG2 is correlation to DNA damage repair and apoptosis through P53 pathway which influences the radiosensitivity.The present study aimed to investigate the radiosensitizat
Objective: Epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI)therapy is considered as one of the most important treatments for patients with advanced non-small-cell lung cancer(NSCLC
Aims: The Maf family proteins belong to the basic leucine zipper transcription factors,including c-fos andc-jun.The transcription factor c-Maf,which is one the Maf family proteins,is extensively invol
Background We tried to summarize the clinical application of Canādells technique in China.Methods We retrospectively reviewed 15 patients who underwent Canādells technique(epiphysiolysis before excisi
Background We tried to determine whether intra-epiphyseal resection for epiphysis preservation could lead to limb discrepancy without increasing the risk of local recurrence or death in patients with