【摘 要】
：
Abdominal aortic aneurysm (AAA), defined as a 50% increase in external diameter of the abdominal aorta, is one of the leading causes of sudden death in aging men.Although hyperhomocysteinemia (HHcy) i
【机 构】
：
Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Peking University,Beij
【出 处】
：
International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Abdominal aortic aneurysm (AAA), defined as a 50% increase in external diameter of the abdominal aorta, is one of the leading causes of sudden death in aging men.Although hyperhomocysteinemia (HHcy) is a strong independent risk factor of coronary heart disease and stroke in human, the association of HHcy and AAA is still an enigma.We subcutaneously infused AngⅡ (1000 ng/kg/min) or saline into 16-week-old male ApoE-/-mice for 28 days to induce AAA.Before implanting, mice was fed with 0, 0.9 g/L, 1.8 g/L Hcy and 1.8 g/L Hcy+folic acid (0.071 g/g/day, equivalent to 5 mg/70 kg/day human dose) in drinking water for 4 weeks, and subsequent 28 days together with AngⅡ or saline infusion.Homocysteine supplement at 0, 0.9 g/L or 1.8 g/L in ApoE-/-mice resulted in 8.12±2.58 M, 16.24±4.48 M or 23.52±3.53 M of plasma bomocysteine level respectively.Although the effect of 0.9 g/L homocysteine treatment did not reach statistical significance compared to that of no homocysteine supplement.Intriguingly, supplementation of folic acid in homocysteine (1.8 g/L) treated and AngⅡ infused ApoE-/-mice resulted in a greatly diminished incidence and severity of HHcy aggravated AAA (folic acid+Hcy+AngⅡ vs.Hcy+AngⅡ: 50% vs.92.3%, P<0.05).Moreover, folic acid treatment dramatically reduced the maximal abdominal aortic diameter, elastin degradation, inflammatory cell infiltration and MCP-1/IL-6 production in the adventitia of suprarenal aorta.These data suggested that homocysteine lowering by folic acid rescued HHcy aggravated AngⅡ-induced AAA formation.It may provide us a new therapeutic strategy for preventing AAA formation.
其他文献
Introduction: Parkinsons disease (PD) is a common neurodegenerative disease, characterized by motor and non-motor symptoms.Depression is the most common psychiatric complication in PD and affects abou
The subthalamic nucleus (STN), a critical target for Parkinsons disease (PD) treatment, receives direct histaminergic projections.However, little is known about the role of histamine in the STN.Here,
Traditional meditation technique (Raja Yoga) affects psychological, behavioral and autonomic functions.The study was aimed to investigate the effects of duration of meditation on cardiovascular autono
This study observed the role of ERK1/2 in the myocardial fibrosis in cultured cardiac fibroblasts.After exposure to aldosterone(Ald) and ERK1/2 inhibitor PD98059, cell cycle, proliferation, P-ERK1/2 e
Objectives Hyperhomocysteinemia (HHcy) accelerates atherosclerosis in apoE-/-mice by promoting T-cell activation, proliferation and inflammatory cytokine secretion, but the mechanism is still unknown.
This study was designed to investigate anti-arrhythmic effect of chronic intermittent hypobaric hypoxia (CIHH) in fructose-induced.metabolic syndrome (MetS) rats.Sprague-Dawley rats were subject to tr
Introduction: To investigate the effect of exercise on biophysical properties of BKca channel during aging in rat cerebral artery smooth muscle cells (SMCs).Methods: Young (2-5 months, Y-SED) and midd
Background Our previous studies demonstrated that Rapamycin overrode the dysregulation of low lipoprotein receptor (LDLR) pathway induced by inflammation.This study was to investigate whether the acti
We thought to determine the effect of ADAMTS-7 (a disintegrin and metalloproteinase with thrombospondin motifs) in angiogenesis.Overexpression of ADAMTS-7 in human umbilical vein endothelial cells (HU
The migration of vascular smooth muscle cells (VSMCs) is the main step in neointimal formation in restenosis and athersclerosis.Tropomodulin1 (Tmod1) is a capping protein of actin filament and express