【摘 要】
：
This study was designed to investigate anti-arrhythmic effect of chronic intermittent hypobaric hypoxia (CIHH) in fructose-induced.metabolic syndrome (MetS) rats.Sprague-Dawley rats were subject to tr
【机 构】
：
Department of Physiology,Hebei Medical University,Shijiazhuang,China
【出 处】
：
International Conference for Physiological Sciences 2012(201
论文部分内容阅读
This study was designed to investigate anti-arrhythmic effect of chronic intermittent hypobaric hypoxia (CIHH) in fructose-induced.metabolic syndrome (MetS) rats.Sprague-Dawley rats were subject to treatment with fructose (10% fructose in drinking water for 6 wks), CIHH (simulated 5000 m altitude, 6 hours per day for 6 wks), and CIHH plus fructose.Ischemia/reperfusion (I/R) arrhythmia was induced by coronary ligation, and action potential (AP) in papillary muscle was recorded by intra-cellular recording technique.MetS rats displayed a severe arrhythmia that was effectively prevented by CIHH treatnent.Also, CIHH prolonged AP duration (APD)under normal condition and antagonized the inhibition of AP during I/R.CIHH confers protective effect against 1/R-induced arrhythmia in the MetS rats, which might be related to the prolongation of APD and prevention of AP inhibition by I/R.
其他文献
Although glucagon-like peptide-1 (GLP-1), an insulin-releasing gut hormone, has been thought as a promising treatment for Alzhermers disease (AD), the natural GLP-1 can be rapidly degraded by the enzy
The globus pallidus plays a significant role in motor control under both health and pathological states.Recent studies have revealed that HCN channels occupy a critical position in globus pallidus pac
Both ginsenoside Rg1 and insulin-like growth factor-Ⅰ (IGF-Ⅰ) has been reported to exert neurotropic and neuroprotective effects on the nervous system.The present study was designed to investigate the
Melatonin, an indole hormone secreted by the pineal gland, has been reported to have strong neuropeotective effects.However, whether melatonin could protect hippocampal synaptic plasticity and neurona
The paraventricular nucleus (PVN) of hypothalamus is a major integrative center in homeostatic control.Morphological studies have revealed a high level of secretin and secretin receptor expression in
Introduction: Parkinsons disease (PD) is a common neurodegenerative disease, characterized by motor and non-motor symptoms.Depression is the most common psychiatric complication in PD and affects abou
The subthalamic nucleus (STN), a critical target for Parkinsons disease (PD) treatment, receives direct histaminergic projections.However, little is known about the role of histamine in the STN.Here,
Traditional meditation technique (Raja Yoga) affects psychological, behavioral and autonomic functions.The study was aimed to investigate the effects of duration of meditation on cardiovascular autono
This study observed the role of ERK1/2 in the myocardial fibrosis in cultured cardiac fibroblasts.After exposure to aldosterone(Ald) and ERK1/2 inhibitor PD98059, cell cycle, proliferation, P-ERK1/2 e
Objectives Hyperhomocysteinemia (HHcy) accelerates atherosclerosis in apoE-/-mice by promoting T-cell activation, proliferation and inflammatory cytokine secretion, but the mechanism is still unknown.