【摘 要】
：
The subthalamic nucleus (STN), a critical target for Parkinsons disease (PD) treatment, receives direct histaminergic projections.However, little is known about the role of histamine in the STN.Here,
【机 构】
：
Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechno
【出 处】
：
International Conference for Physiological Sciences 2012(201
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The subthalamic nucleus (STN), a critical target for Parkinsons disease (PD) treatment, receives direct histaminergic projections.However, little is known about the role of histamine in the STN.Here, we show that histamine excites the STN neurons via H2 receptors.Moreover.histamine promotes motor performances in normal rats by activation of STN neurons.Furthermore, unilateral microinjection of histamine into the STN of the 6-OHDA-lesioned rat considerably reduces apomorphine-induced animals rotations.Intriguingly, in PD rather than normal rats, histamine not only increases firing rates but decreases coefficient of variation of interspike intervals of STN neurons.These results demonstrate that histamine excites and regularizes neuronal firing patterns in the STN and subsequently rescues motor performances of PD rats, suggesting that the central histaminergic nervous system may actively modulate the basal ganglia circuits and consequently regulate motor initiation and performance
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