【摘 要】
：
Cholinergic neuron and glutamatergic neuron are two main types of neuron in the Medial Septum (MS),which all directly project to the hippocampal formation.However, there is few evidence showing which
【机 构】
：
Department of Physiology,Key Laboratory of Cellular Physiology,Ministry of Education,Shanxi Medical
【出 处】
：
International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Cholinergic neuron and glutamatergic neuron are two main types of neuron in the Medial Septum (MS),which all directly project to the hippocampal formation.However, there is few evidence showing which type of neuron is responsible for the amyloid β-protein (Aβ)-induced deficits in cognitive function and synaptic plasticity.The present study examined the effects of MS injection of Aβ25-35 and Kainic acid (KA) on the spatial memory and hippocampal long term potentiation (LTP) by using Morris water maze (MWM), reversal MWM (rMWM), Y maze (YM) and in vivo field potential recording techniques.We found that: (1) Aβ25-35 (5 nmol), not KA (0.75 μg),injection seriously impaired the learning and memory of rats in hidden platform tests and probe tests, respectively;(2) Both Aβ25-35 and KA injection decreased the retention time of rats in the novel arm of YM in spontanous spatial novelty preference test;(3) MS injection of Aβ25-35, not KA, significantly suppressed hippocampal LTP in CA1 region.These results indicate that Aβ25-35, by damaging cholinergic neurons, could inhibit hippocampal synaptic plasticity and impair the spatial reference memory, cognitive flexibility and spatial working memory of rats, while KA, by damaging glutamatergic neurons, only impaired the spatial working memory of rats, suggesting that Aβ-induced impairment of cholinergic system in MS may be more closely involved in the cognitive deficits seen in Alzheimers disease.
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