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The rapid advance in next-generation sequencing (NGS) technologies has made it possible to sequence individual genomes in a cost-efficient and timely manner.There has already been massive amount of NGS data available and much more will be generated in the near future.Correspondingly, personalized genomics is emerging as a new research field.In the first part of this talk, I will introduce personalized genomics approach in translational medicine using our melanoma whole genome sequencing project as an example.Through whole genome sequencing and analysis of a highly aggressive melanoma, we identified critical BRAF L597 mutants that are associated with sensitivity to MEK inhibitors.Our study demonstrates the utility of whole genome sequencing in identifying actionable mutations in tumors and potential therapeutic implications of BRAF L597 mutations in melanoma.In the second part,I will introduce a pilot project to infer personalized pathway enrichment map of putative cancer genes from next generation sequencing data.Finally, I will discuss the challenges on personalized genomie data analyses.