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Objective: In recent years, increasing clinical evidence indicates that long-term use of an anti-angiogenesis drug bevacizumab can promote tumor cell metastasis.This study was to investigate the underlying mechanism involved.Methods: Oral squamous cancer cell WSU-HN6 cells were treated with 50 μg/mL bevacizumab for 72 h, then subjected to detect the invasion ability via Transwell system.Meanwhile, the treated cells were harvested to do western blotting analysis.