【摘 要】
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Objective: This study reports the in vitro and in vivo biological activities of recombinant human bone morphogenetic protein 2 (rhBMP-2) released from the core-shell structure of a nanofibrous barrier
【机 构】
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Department of Oral and Maxillofacial Surgery,First Affiliated Hospital,College of Medicine,Zhejiang
【出 处】
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11th Asian Congress on Oeal and Maxillofacial Surgery(第十一届亚洲
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Objective: This study reports the in vitro and in vivo biological activities of recombinant human bone morphogenetic protein 2 (rhBMP-2) released from the core-shell structure of a nanofibrous barrier membrane as a sustained delivery model for bone regeneration.Methods: RhBMP-2 incorporating poly(ethylene glycol) was used as the core, and poly(caprolactone) was used as the shell surrounding the core.To determine its release profiles, the release solution was collected and the amount of rhBMP-2 was measured by EL1SA at different time points.The distribution and proliferation of BMMSCs in the nanofibrous barrier membrane was measured by laser confocal scanning microscopy (LCSM) and scanning electron microscopy (SEM).The biological activity of rhBMP-2 was tested in BMMSC/membrane culture in vitro and in a rabbit calvarium defect model in vivo.
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