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Hepatocellular carcinoma (HCC) is one of the most common liver cancers and is the third leading cause for mortality among malignant neoplasms [1].However,it remains a challenge to increase cellular uptake and tumor-selectivity of cancer drugs as well as to achieve sustained drug release for chemotherapy.In the present study,we developed a dual-functional biodegradable micellar system named glycyrrhetinic acid-poly (ethylene glycol)-graft-poly(lactic-co-glycolic acid) polymers (GAPEG-SS-PLGA).