Targeting exosomal miRNA with pH-sensitive liposome coated chitosan-siRNA nanoparticles for inhibiti

• 作 者: NaWu[1]XinxinZhang[2]JuanLi[3]YongGan[2]
• 机 构: School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China
• 出 处: The Third Symposium on Innovative Polymers for Controlled De
• 发表日期: 2014年期

　　In the past decade,extracellular microRNAs (miRNAs) have emerged as important mediators in intercellular communication,promising biomarkers for diagnosis and therapeutic agents for targeted treatment.Exosome-mediated transfer of microRNA is capable of stimulating tumor progression.The internalization of exosomal miRNAs from metastatic cancer cells into non-cancerous cells could deliver metastatic signals and result in cancer metastasis.Fortunately,sphingosine kinase2 (SphK2) was found to be an essential regulator for cargo sorting into ILVs destined for exosomal release [1].By using an efficient siRNA delivery system,we hope to reduce the secretion of exosomal miRNAs from metastatic liver cancer cells and to realize inhibition of hepatocellular carcinoma metastasis.