【摘 要】
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Aim of study:To investigate the pharmacological effects and mechanism of Danggui-Shaoyao-San (DSS) on liver cirrhosis ascites,which is the classic symptoms of unsmmoth blood circulation results in wat
【机 构】
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School of Materia Madica,Anhui University of Traditional Chinese Medicine,Anhui,Hefei 230031,China
【出 处】
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世界中医药学会联合会中药药理专业委员会第七届学术会议、全国中药药理联合会第二届学术年会暨第20届中日健康学术研讨会
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Aim of study:To investigate the pharmacological effects and mechanism of Danggui-Shaoyao-San (DSS) on liver cirrhosis ascites,which is the classic symptoms of unsmmoth blood circulation results in water retention.To evaluate the function of DSS and its decompositions on rats mode with liver cirrhosis ascites,To evaluate the function of DSS and its decompositions on rats mode with liver cirrhosis ascites,from the perspective of electrolyte metabolism.Examining the e任.eects of the activating blood component (which compsed of angelica,peony,chuanxiong) and the promoting water component(which compsed of poriacocos,alisma thizoma,atractylodes) through comparing DSS with its decompositions,so as to clarify the compatibility of science.Material and methods:Male SD rats were randomly divided into the normolcontrol group,the model group,Danggui Shaoyao San low,middle and high dose groups,the activating blood group,the promoting water group.The cirrhotic ascites rat model was established by CC14 combined with Phenobarbital.Metabolic cages were used to collect urine in 24 hours of rats.Urine osmotic pressure was detected by cryoscopy.The levels of K+.Na+.Cl-were detected by the automatic biochemistry analyzer.Results:Compared with the model group,urine osmotic pressure decreased in groups of Danggui-shaoyao-san.The serum level of K+.Na+.C1-increased greatly while the urine level of K+.Na+.Cl-decreased significantly.Conclusions:Danggui-shaoyao-san has certain corrective action on ascites of cirrhosis rats with electrolyte disorder.
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