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Objective:To analyze the effects of Munzij and Mushil based psychological intervention on the occurrence and development of vitiligo.Methods:Patients with vitiligo were grouped randomly with the help of Hamilton Anxiety Scale (HAMA) and Depression Scale (HRDS) score.Every group except for normal control group was treated with Munzij and Mushil and given psychological intervention at the same time.Serum CRH,ACTH and Cortisol levels were determined and compared with normal control group to identify the effect of psychological intervention.Results:(1)Anxiety and depression of vitiligo patients who are in advanceing and stable phase are significantly severe than normal contrast,stable phase are less severe than advanceing phase,but have no significance.(2)1n the assay for the HPA axis hormone levels,stable phase patients cortisol levels are significantly lower than advancing phase patients and normal persons,the differences are statistically significant.(3) After psychological intervention,the intervention group patients efficacy and HAMA,HRSD score was significantly lower than non-intervention group.Conclusion:Incidence of vitiligo is closely related to changes in patients Neuroendocrine-Immune network,HPA axis changes in hormone levels play an important role on the pathogenesis,including stress factors like anxiety and depression make a variety of hormones body changes in the body,The mechanism may be as follows:Cortisol levels of vitiligo patients with high expression can induce the activity of liver tryptophan pyrrole enzymes,the latter degradation of tryptophan in the blood,resulting in the lack of central tryptophan and 5-HT synthesis decreased.Trigger depression,obsession,anxiety and other symptoms in turn affect the tyrosine metabolism,cause or aggravate vitiligo.Vitiligo patients treated with psychological intervention on the bases of Uyghur Medicine Munzij and Mushil treatment can recover from diseased internal environment state of imbalance,relieve from mental pressure and have improvement in the quality of life,then get significant improvement in the curative effect.