论文部分内容阅读
Objective The mitochondrial enzyme 3-mercaptopyruvate sulfurtransferase (MPST) is a source of endogenous hydrogen sulde (H2S), a gaseous signaling molecule implicated in a wide range of physiological processes.Nonalcoholic fatty liver disease (NAFLD) is currently considered to be the most common liver disorder in western countries, and is rapidly becoming a serious threat to public health.The mechanisms of pathogenesis underlying NAFLD remain unclear at present.The possible role of MPST in the development of NAFLD has never been investigated.A variety of cellular and molecular approaches were used to study the effects of MPST on hepatic steatosis, oxidative stress and inflammation involved in NAFLD.