Effects of simvastatin on hypertrophy and protein kinase B expression of rat cardiomyocytes

• 作 者: CHENYong-Qing[1]ZHAOLian-You[2]ZHANGWei-Ze;MALing;
• 机 构: Department of Cardiology Lanzhou General Hospital Lanzhou Military Command Lanzhou 730050 China
• 出 处: 第17届全军心血管内科学术会议
• 发表日期: 2011年期

　　Objective To study the effects of simvastatin on the serum-induced hypertrophy of cultured rat cardiomyocytes, and to investigate the role of phosphoinositide 3-kinase (PI3K) /protein kinase B (PKB) pathway in the related mechanism.Methods Cardiomyocytes were derived from neonatal Sprague-Dawley (SD) rat.