Expression, purification and characterization of a recombinanthumanized bispecific antibody targetin

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：zhaoguopu

【摘要】

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【作者】

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吴毅于敏

【机构】

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The Key Laboratory of Molecular Medicine, the Ministry of EducationDepartment of Biochemistry and Mo

【出处】

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

：

2014年3期

【关键词】

：

bispecific antobody PD-1 c-MET HEK 293

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A recombinant humanized bispecific antibody(rh BsAb), recognizing programmed celldeath protein 1 (PD-1) and hepatocyte growth factor receptor (HGFR or c-MET) was constructedwith two monoclonal antibodies (mAbs), which were obtained from hybridomasand modified by aligning with human antibody database and screening through DiscoveryStudio software.

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Expression, purification and characterization of a recombinanthumanized bispecific antibody targetin

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