Fragrant agarofuran and eremophilane sesquiterpenes in agarwood 'Qi-Nan' from Aquilaria si

来源 :2014年度中国热带作物学会遗传育种专业委员会/热带香料饮料作物专业委员会年会暨学术研讨会 | 被引量 : 0次 | 上传用户:zhaoshi88
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  Phytochemical analysis of the high quality Chinese agarwood Qi-Nan originating from Aquilaria sinensis (Lour.) Glig, led to the isolation of four fragrant sesquiterpenes, including an agarofuran 4-hydroxyl-baimuxinol (1) and three eremophilanes,7b-H-9(10)-ene-11,12-epoxy-8-oxoeremophilane (2), 7a-H-9(10)-ene-11,12-epoxy-8-oxoeremophilane (3), neopetasane (4).Among them, compounds 1-3 were new compounds.Their structures were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses.Eremophilane sesquiterpenes 2-4 showed inhibitory activities against acetylcholinesterase with IC50 value of 274.8, 491.4, and 158.3 mM, respectively.
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