【摘 要】
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Second generation MOE Gapmer antisense oligonucleotides have demonstrated great promise and clinical activity when employed as a therapeutic modality to tar
【出 处】
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The 3rd Canton Nucleic Acids Forum(第三届广州核酸国际论坛)
论文部分内容阅读
Second generation MOE Gapmer antisense oligonucleotides have demonstrated great promise and clinical activity when employed as a therapeutic modality to target genes expressed in liver.However, the robust targeting of certain extra hepatic tissues, particularly tumors has been more challenging.This presentation will highlight recent advances with next generation cEt ASOs, including the preclinical proof of concept for targeting several extrahepatic tissues including tumors and the clinical translation of these findings to human cancer studies.
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