【摘 要】
：
Th17 cells, which have been characterized as a lineage of effector helper T cells that produce IL-17A, IL-17F, IL-21 and IL-22, has been suggested to be the cri
【机 构】
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ZhejiangUniversity,Hangzhou
【出 处】
：
TGF-β Signaling and Diseases Symposium(TGF-B信号转导与疾病专题研讨会)
论文部分内容阅读
Th17 cells, which have been characterized as a lineage of effector helper T cells that produce IL-17A, IL-17F, IL-21 and IL-22, has been suggested to be the critical drivers of autoimmune inflammation.TH17 cells are present at the sites of tissue inflam-mation and are associated with the induction of many autoimmune diseases,including multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis.The differentiation of TH17 cells is instructed and critically regulated by various cytokines in the microenvironment in the body, which drive intracellular signaling process and transcription profiles that determine the cell fate.In this work, we showed that MINK1, a germinal center kinase (GCK) family kinase, plays as a negative regulator for TH17 cell differentiation.
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