CCR2-mediated Abnormal Excitatory Synaptic Plasticity in the Nucleus Accumbens Contributes to Neurop

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户：tanxiaoxi

【摘要】

：

　　Symptoms including anhedonia, decreased motivation and depression are common affective features in patients with chronic pain.Recent evidence implicated tha

【作者】

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Xiao-BoWu;BiaoLiang;Peng-BoJing;Zhi-JunZhang;Yong-JingGao;

【机构】

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Pain Research Laboratory, Institute of Nautical Medicine, Nantong University,Nantong, Jiangsu 226001

【出处】

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The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)

【发表日期】

：

2015年期

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　　Symptoms including anhedonia, decreased motivation and depression are common affective features in patients with chronic pain.Recent evidence implicated that pathological adaption in the nucleus accumbens (NAc) medium spiny neurons regulates motivation during chronic pain.CC-chemokine receptor 2 (CCR2), a dominant receptor for monocyte chemoattractant protein-1 (MCP-1) has been the focus of attention because of its facilitative effect on nociceptive signal processing in chronic pain at peripheral nerve and dorsal horn.However, it is limited in understanding the effects of CCR2 in synaptic transmission in NAc, which functions to gate motivation and emotion for behavioral output.

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