论文部分内容阅读
Background/Aims Natural killer cells (NK)-expressing TRAIL have capacity to mediate hepatocyte apoptosis in HBeAg-negative chronic hepatitis B (CHB) patients with liver flare; however, it remains unknown that the characteristics of NK TRAIL in HBeAg-positive CHB patients.Methods Peripheral blood was obtained from 18 HBeAg + CHB patients with high levels of ALT (IA), 16 of immune tolerant (IT) subjects and 18 healthy controls (HC).TRAIL expression by NK cells was examined by using flow cytometry.We also analyzed the correlation between TRAIL expression and NK cytolytic activity in these patients.Finally, the influence of IFN-α on TRAIL expression was detected both in vitro and in vivo.