论文部分内容阅读
Aims The long-term outcome of lamivudine therapy in HBeAg-positive chronic hepatitis B patients previously treated with IFN has rarely been reported.The aim of thhis study was to investigate the long-term efficacy of lamivudine therapy and the possible influence of prior IFN treatment on the outcome in these patients.Methods This was a retrospective case-control study.The data were collected from the patients who had received lamivudine therapy for at least 2 years and been followed up for at least 6 months, and the patients were either with previous IFN treatment or without any antivial history before lamivudine initiation, and all with baseline HBV DNA levels ranged from 6 to 7 log copies/ml.IFN-experienced group and IFN-free group were divided resoectively, and the biochemical, serological and virological data during treatment and follow-uo were analysed.