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  5. Rapamycin modulates the course of hepatitis B virus (HBV) infection in hydrodynamic injection mouse

Rapamycin modulates the course of hepatitis B virus (HBV) infection in hydrodynamic injection mouse

来源 :中华医学会第十六次全国病毒性肝炎及肝病学术会议 | 被引量 : 0次 | 上传用户：tianshi6868
【摘 要】
：
Background Hydrodynamic injection (HI) of pAAV/HBV1.2 inBALB/c mice leads to a transient HBV gene expression and replication in liver, representing a useful system for the study of HBV infection.Rapam
【作 者】
：
Shunmei Huang Zhitao Song Baoju Wang Junzhong Wang Zhenni Zhu Bin Zhu Xuemei Feng Mengji Lu Dongliang Yang 
【机 构】
：
Department of Infectious Diseases, Union Hospital of Tongji Medical college,Huazhong University of S
【出 处】
：
中华医学会第十六次全国病毒性肝炎及肝病学术会议
【发表日期】
：
2013年7期
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Background Hydrodynamic injection (HI) of pAAV/HBV1.2 inBALB/c mice leads to a transient HBV gene expression and replication in liver, representing a useful system for the study of HBV infection.Rapamycin (RAPA) can selected activated Treg in vitro.In this study, the effect of RAPA on HBV replication was investigated in HBV HI mice model, and the possible role of Treg in HBV persistence was analyzed using RAPA treated mice model.
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