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Metastasis is the main cause of cancer-related death.Despite improvement in cancer diagnosis and therapy,diminished sensitivity to chemotherapy and acquired resistance are still limit the treatment efficacy.Thus,a continuous real-time monitoring is quite important during clinical therapy.Circulating tumor cells in peripheral blood can provide repeatedly and non-invasively monitor of therapeutic responses.Until now,most of the technologies are based on antibody-based isolation including CellSearch system.Epithelial cell adhesion molecule(EpCAM),a stem and carcinoma cell marker on cell surface,is used as a diagnosed marker.While widespread clinical application of the antibody-based CTC isolation techniques is still limited by the stability,reproducibility,mass production and expensive price.