【摘 要】
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Currently,detection methods for biomedical analysis,especially in clinical assays of body fluids,rely primarily on optical,magnetic,or electrochemical measurements.However,considering the need for low
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Currently,detection methods for biomedical analysis,especially in clinical assays of body fluids,rely primarily on optical,magnetic,or electrochemical measurements.However,considering the need for low-cost analyses by inexperienced personnel,for example in field operations or point-of-care scenarios,these methods suffer from inherent limitations.Herein,we demonstrate that a very familiar,yet underutilized,physical parameter—gas pressure—can serve as signal readout for highly sensitive bioanalysis.Integration of a catalyzed gas generation reaction with a molecular recognition component leads to significant pressure changes,which can be measured with high sensitivity using a low-cost and portable pressure meter.In particular,we have combined the decomposition of H2O2 catalyzed by catalase or Pt nanoparticles with either an antibody-based sandwich assay or a target-responsive DNA hydrogel for detection of various analytes.This new signaling strategy opens up a new way for simple,portable,yet highly sensitive biomedical analysis in a variety of settings.
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