Deregulated HOXB7 Expression Predicts Poor Prognosis of Patients with Esophageal Squamous Cell Carci

• 作 者: HuiLi[1]Lu-YanShen[1]Wan-PuYan[1]BinDong[2]Xiao-ZhengKang[1]LiangDai[1]Yong-BoYang[1]HaoFu[1]He-LiYang[1]Hai-TaoZhou[1]ChuanHuang[1]ZhenLiang[1]Hong-ChaoXiong[1]Ke-NengChen[1]
• 机 构: Department of Thoracic Surgery Ⅰ,Key Laboratory of Carcinogenesis and Translational Research (Minist
• 出 处: 中国医师协会胸外科医师分会2015年会、第六届全国胸外科学术大会暨第八届浙江省胸部肿瘤论坛
• 发表日期: 2015年期

　　Background:We observed abnormal HOXB7 expression in esophageal squamous cell carcinoma (ESCC)previously.This study was to evaluate the prognostic significance of HOXB7 and reveal the potential mechanism.Methods:Immunohistochemistry was used to confirm the abnormal expression of HOXB7 in ESCC.The prognostic significance of HOXB7 expression was analyzed in two independent cohorts.RNAi was used to establish two stable HOXB7-knockdown cell strains.CCK8 assay, cell growth curve assay,colony formation assay ,flow cycle analysis and tumorigenicity assay in nude mice were employed to investigate the effect of HOXB7 on proliferation in vitro and in vivo.