Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：bianhao9527

【摘要】

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Histone modifications play critical roles in regulating the expression of developmental genes during embryo development in mammals.Here,by using a small-scale chromatin immunoprecipitation sequencing

【作者】

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刘晓雨王晨飞刘文强李静一李翀寇晓晨陈嘉瑜赵艳红高海波王红张勇高亚威高绍荣

【机构】

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上海第一妇幼保健院临床与转化研究中心,上海市信号转导与疾病研究重点实验室,学与技术学院,上海200092;北京协和医科大学研究生院,北京100730;北京生命科学研究所,北京102206

【出处】

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第七届全国生物信息学与系统生物学学术大会

【发表日期】

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2016年8期

【关键词】

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mouse embryo development histone modifications ChIP-seq broad H3K4me3

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　　Histone modifications play critical roles in regulating the expression of developmental genes during embryo development in mammals.Here,by using a small-scale chromatin immunoprecipitation sequencing (ChIP-seq) method,for the first time,we mapped the genome-wide profile of histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 27 trimethylation (H3K27me3) in mouse pre-implantation embryos.

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Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

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