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Dendritic cell (DC)-based immunotherapy has been expected to shed lights on the field of cancer treatments.However.even in the murine model,DC-based immunotherapy has not been as much effective as expected in most solid tumor.Our investigation was initiated to identify what causes the limitations of DC-based immunotherapy in solid tumor.We found that the limitation of DC vaccine to solid tumor is likely due to the tumor-mediated TGF-β rather than insufficient immune induction.