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目的 利拉鲁肽是一种人胰高糖素样肽1(GLP-1)类似物,能够有效的改善β细胞的功能.然而是否利拉鲁肽能在脂毒性的环境中发挥该作用尚不清楚.本研究拟探讨利拉鲁肽对脂毒性所致β细胞功能受损的保护性作用,并且探明相关的分子机制.
利拉鲁肽通过磷脂酰肌醇3激酶/蛋白激酶B/叉头状转录因子O1信号通路对脂毒性所致β细胞功能受损的保护性作用
【摘 要】
：
目的 利拉鲁肽是一种人胰高糖素样肽1(GLP-1)类似物,能够有效的改善β细胞的功能.然而是否利拉鲁肽能在脂毒性的环境中发挥该作用尚不清楚.本研究拟探讨利拉鲁肽对脂毒性所致β细胞功能受损的保护性作用,并且探明相关的分子机制.
【机 构】
：
华中科技大学同济医院内分泌科
【出 处】
：
中华医学会糖尿病学分会第十七次全国学术会议
【发表日期】
：
2013年7期
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