金黄色葡萄球菌纤粘蛋白的研究进展

来源 :2015年中国微生物学会学术年会 | 被引量 : 0次 | 上传用户：zhangf123456

【摘要】

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【作者】

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容冬丽吴清平徐明芳张菊梅

【机构】

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广东省微生物研究所,省部共建华南应用微生物国家重点实验室,广东省菌种保藏与应用重点实验室,广东省微生物应用新技术公共实验室,广东广州 510070;暨南大学生命科学技术学院,广东广州 510006

【出处】

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2015年中国微生物学会学术年会

【发表日期】

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2015年5期

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金黄色葡萄球菌属于重要的机会性致病菌,能引发表皮感染,甚至引发化脓性关节炎、心内膜炎等,该致病菌在播散感染初期,黏附素(纤粘蛋白、纤黏蛋白原凝集素、胶原结合蛋白、A蛋白和骨唾液蛋白结合蛋白等)在生物膜形成及稳定地维持病原菌在宿主体内起到关键作用.几乎所有的金黄色葡萄球菌都有纤粘蛋白(Fnbp),其包括纤黏蛋白A和纤黏蛋白B(Fnbp A和Fnbp B),是由两个同源性相近基因编码的细胞壁结合蛋白,二者具有的黏附作用基本相同.本文就最近几年学者们在金黄色葡萄球菌Fnbp研究领域进行综述.有研究证实Fnbp是一种多功能粘附素,可结合纤维蛋白和弹性蛋白等,其中FnbpA至少有7种结构不同的亚型,可能的作用是帮助金黄色葡萄球菌躲避宿主的免疫反应.

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金黄色葡萄球菌纤粘蛋白的研究进展

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