Regulatory T (Treg) cells characterized by the transcription factor FoxP3 have a fundamental role in the establishment and maintenance of peripheral toleran
B lymphocytes are generally recognized for their potential to mediate humoral immunity by producing different antibody isotypes and being involved in opsoni
Interferon regulatory factor 4 (IRF4) regulates the transcription of genes essential for the differentiation and function of multiple Th/Treg subsets, inclu
Background: Activation of CD4+T cells play a pivotal role in renal ischemia reperfusion injury.Galectin-9 (Gal-9) is a T-cell immunoglobulin domain and T mu
Ubiquitination has been reported as one of major regulating mechanisms of T-cell activation.Studies on Cbl, ITCH and GRAIL have highlighted that the ubiquit