Aim βguanadinopropionic acid (βGPA), a creatine analog has been demonstrated to lead to the chronic activation of AMPK with increasing mitochondrial biogenesis.However, little is known about the effec
A large body of epidemiological and clinical evidences indicated that smoking has a protective effect in patients with ulcerative colitis (UC).Although it is generally believed that nicotine accounts
Aim To investigate the role of CKLF1 in SHSYSY cell migration and its molecular regulatory mechanism.Methods SHSY5Y cells were stimulated with CKLF1 for 0.5, 2, 8 and 24 h, respectively.The migration
Hypoxia preconditioning (HPC) is associated with many complicated pathophysiological and biochemical processes that integrated and regulated via molecular levels.HPC could protect cells, tissues, orga
Purpose: Fibronectin type Ⅲ domaincontaining protein 5 (FNDC5), also known as irisin, is a myokine secreted from muscle in response to exercise and improves obesity and glucose homeostasis.However, th
Insulin sensitizing medicines are currently limited, and identification of new drug candidate is a challenge.Protein tyrosine phosphatase 1B (PTP1 B) negatively regulates insulin signaling pathway, an
In silico prediction of drugtarget interactions from heterogeneous biological data can advance our systemlevel search for drug molecules and therapeutic targets, which efforts have not yet reached ful
Exosomes ( EXs, 30~120 nm) and microvesicles ( MVs, 100~ 1000 nm) are two types of extracellularmicroparticles. Their contents (miRs and proteins) vary depending on cell origin and status. Mounting ev
PDE is a superfamily of enzymes that break down the important second messengers cyclic AMP ( cAMP)and cyclic GMP ( cGMP) . There are 11 PDE families ( PDEl11); among them , PDE4 is the most important
Depression is a recurring and potentidly lifethreatening disorderthat is major cause of morbidity and mortality. Stressful eventscan precipitate factors in the onset of major depressionand stress para